Rabbits are a popular choice for research animals because they are small, inexpensive, and easy to care for. Monoclonal antibodies (mAbs) are specific proteins that are made by the body’s B cells in response to an antigen. mAbs can be isolated from the blood of rabbits using a process called affinity chromatography. In this process, the antibodies bind to a particular tag or target molecule and can be separated from other proteins in the sample. Navigate to this site for more information about rabbit monoclonal antibody service.
There are several steps involved in producing a rabbit mAb. The first step is to collect blood from a rabbit that has been infected with the virus or disease of interest. The blood should be processed immediately so that the antibodies can be extracted and concentrated.
Next, mAbs are generated by immunizing rabbits with the antigen of interest. After the rabbits have developed immunity, they are then subjected to an immune response test in which they are challenged with increasing doses of antigen.
Finally, the mAbs that are generated in this process are purified and characterized. (a) Specific and non-specific immune mechanisms for neutralization of a virus. Two molecules, two antibodies, or an antibody and a receptor can neutralize a viru.
These monoclonal antibodies are produced by hybridoma cultures (obtained from mice immunized against influenza) that contain monoclonal antibodies able to bind to sites on the viral envelope proteins of isolates of virus-like particles.